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CagA binds to the PAR1b via the CM sequence, which induces CagA dimerization. Upon the complex formation, CagA inhibits PAR1b kinase activity and thereby causes ...
Tyrosine-phosphorylated CagA specifically binds and deregulates SHP-2 via the Western CagA-specific EPIYA-C or East Asian CagA-specific EPIYA-D site, and Csk via the EPIYA-A ...
Abstract; Recent molecular analysis has provided the pathological actions of CagA on gastric epithelial cells. CagA is injected into epithelial cells via the type IV ...
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